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The Tricarboxylic Acid Cycle While the TCA cycle is commonly thought of as an NADH and FADH 2 producing pathway, it also generates NADPH

Importantly, inhibition of baseline Notch signaling in fully transformed human cell lines did not alter sensitivity to GPX4 inhibition, further supporting the conclusion that Notch activation at tumor inception forces an astrocytic developmental trajectory with altered mitochondrial activity but Notch activation later in tumor development is not sufficient to induce similar cell states, metabolic programs, or therapeutic vulnerabilities

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found that the differentiation of PC-12 cells (neurons) involves an increase in intracellular copper (Chakraborty et al., 2022)

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