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This reliance of NSCs on proper NRF2 function was further confirmed using an Nrf2 / mouse, which exhibited fewer SVZ NPCs than wild-type mice, with surviving Nrf2 / NSCs proliferating less and exhibiting decreased neurogenic potential (Corenblum et al., 2016

240 It has also been shown that MTA accumulation and secretion occur in MTAP-deficient GBM, but no significant MTA accumulation was detected in vivo because the stromal cells in the TME express WTAP and consume the MTA emitted by tumor cells and increase the activity of PRMT5

In this case, time-to-peak was prolonged, consistent with slower depletion of a larger store, whereas decay kinetics were unchanged, indicating unaltered Ca clearance mechanisms

individual sources vary

24 h after transfection, cells were washed with 1xPBS and incubated with different media conditions for 8 h