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Similarly, sublingual (under-the-tongue) glutathione showed superior effects compared to both NAC and regular oral glutathione in improving antioxidant status

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Abbreviations ANOVA: KruskalWallis analysis of variance ATTR: Transthyretin amyloidosis AUC: Area under the curve CV: Coefficient of variance dsNNTTR: Aggregation-prone TTR species DPD: 99mTc-DPD, 3,3-diphosphono-1,2-propanodicarboxylic acid GSH: Glutathione GSSG: Glutathione disulphide GCL: -glutamylcysteine synthetase / glutamatecysteine ligase GPx: Glutathione peroxidase GSNO: S-nitrosylglutathion IDO : Indoleamine 2,3-dioxygenase 1 IQR: Interquartile range IS: Internal standard KEGG: Kyoto Encyclopedia of Genes and Genomes Kyn/Trp: Kynurenine/tryptophan LC/MS TOF: Liquid chromatographytime-of-flight mass spectrometry LOD: Limit of Detection LOQ: Limit of Quantitation MRM: Multiple Reaction Monitoring NNTTR: Non-native fold of TTR NPH: Nitrophenyl hydrazine PGA: Pyroglutamic acid p : MannWhitney U test significance score RNS: Reactive nitrogen species ROC: Receiver Operating Characteristic ROS: Reactive oxygen species S/N: Signal-to-noise ratio TCEP: Tris (2-carboxyethyl)phosphine TTR: Transthyretin References Saraiva MJ, Birken S, Costa PP, Goodman DS

While iron is incredibly important to the proper operation of many different biological systems, it can also cause free radical damage if it isn't properly handled