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The flies solely administered with L-DOPA performed better during initial exposure after which their progress declined, consistent with the reported pattern of wearing-off in L-DOPA administered PD patients 39,55

On the one hand, many scholars have proposed to change the composition and molecular structure of SOD by chemical modification, point mutation, liposome modification, and microencapsulation [101,102,103,104] without changing its biological activity so as to improve its stability [105]

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