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Additionally, at least five ancillary symptoms must be present, such as limb heaviness or generalized weakness, diminished concentration, or attention, decreased motivation or interest in usual activities, insomnia or hypersomnia, nonrestorative sleep, perceived need to struggle against inactivity, pronounced emotional response to fatigue, perceived short-term memory issues, or prolonged malaise following exertion (11)

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For example, during clinical trials for Simvastatin and Ezetimibe combination therapy for aortic-valve stenosis, cancer was suspected as a side-effect as the placebo group had only 65 instances of cancer compared to 101 amongst those receiving the drugs, with cancer-related deaths around proportionately higher (20 to 37)