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Numerous and mostly flawed past clinical trials of agents engaging diverse pharmacological targets yielded inconclusive or negative results.Reference Bhidayasiri, Fahn and Weiner 141 , Reference Soares-Weiser and Fernandez 143 , Reference Caroff, Campbell and Carroll 157 - Reference Soares-Weiser, Rathbone, Ogawa, Shinohara and Bergman 159 In contrast, recent trials have provided robust evidence on the efficacy and tolerability of valbenazine and deutetrabenazine (Table 4)

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Chemical synthetic glutathione often involves toxic organic solvents (e.g., monochloroacetic acid) and faces strict regulatory bans in natural food/supplement categories in Europe and North America