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This process is also known as cell turnover

Trizzino et al showed that enhancers associated with the inflammatory response are EGR1 target regions in macrophages, and Egr1 represses inflammatory enhancers in developing and mature macrophages, thus attenuating the immune response [73]

& Docking, S

Therefore, it is impossible to determine if IN GHK-Cu actually restored the aged hippocampus to a youthful transcriptomic state, or if it pushed the tissue into a novel, alternative compensatory state that simply happens to function better

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