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Clin Chem Lab Med (2003) 41:12818

Cardiovascular Support Investigated for its ability to improve ejection fraction and survival rates in models of heart failure by normalizing oxidative phosphorylation profiles without inducing pathological hypertrophy

Researchers considering extended protocols should be aware that this safety gap exists and should monitor for unexpected effects in tissues where NNMT has normal physiological functions

That does not make them all equivalent, but it does mean that any clinic presenting them as proven, or glossing over the difference between an off-label prescription and an unapproved compound, is getting well ahead of the evidence, and you should treat that as a signal about the clinic