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Brukinsa, in combination with Genentechs Gazyva, is now authorized for the third-line treatment of relapsed or refractory follicular lymphoma (FL)

For instance, while alkylamine-based degraders could be leveraged against FKBP12, NSD2, and XIAP, an informer set of alkylamines conjugated to the BET bromodomain ligand JQ1 failed to induce proximity and ensuing degradation of the BET protein BRD4, a target that is otherwise frequently utilized for degrader proof of concept studies

Patients have described it as Ive been born again, says Green

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iScience 23:100984 Longtine MS, McKenzie 3rdA, Demarini DJ, Shah NG, Wach A, Brachat A, Philippsen P, Pringle JR (1998) Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae