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Despite the liver and brains capacity to convert ALA into DHA, the endogenous synthesis of EPA and DHA in the brain is relatively low, necessitating their active uptake from the bloodstream (54, 56)

Emerging evidence reveals their significant potential as therapeutic targets for a spectrum of disorders, including anemia, diabetes, malignant muscular dystrophy, and liver fibrosis

Fer1 (S7243), DFO (S5742), chloroquine (CQ, S6999), 3-methyl adenine (3-MA, S2767), Olaparib (S1060), NSC118218 (S1491), and Glumetinib (SCC244, S8676) were purchased from Selleck Chemicals (Houston, USA)

Baseline and periodic blood pressure measurements, particularly in patients with cardiovascular disease or those taking cardiovascular medications, would identify any clinically significant hemodynamic effects

doi: 10.1172/jci38499 73 KikuchiHPinoMSZengMShirasawaSChungDC