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21677085, 21537001 and 81472986) and the Project funded by China Postdoctoral Science Foundation (No 2016 M590071)

Wolstenholme, & A

Computational screening of natural MtbDXR inhibitors for novel anti-tuberculosis compound discovery

These molecules can further induce various transcription factors, like NF-B, STAT, p53, and activator protein-1 (AP-1) [9]

At the genetic level, two common functional polymorphisms, C677T (rs1801133) and A1298C (rs1801131), are widely studied for their effects on enzyme thermolability and folate/homocysteine status