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Interestingly, N-terminal truncation of A peptides yields variants such as A(4-x) and A(11-x) with three orders of magnitude higher Cu(II) affinity 14,15 , where x can be either 40 or 42

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Claudins 3, 5 and 8 as well as occludin and JAM-A have all been observed to be internalized rather than expressed on the membrane in biopsies from patients with colitis [156]

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Mitochondrial cascade hypothesis: Mitochondrial dysfunction and the accumulation of reactive oxygen species lead to neuronal damage and ultimately contribute to the pathogenesis of neurodegenerative diseases, particularly AD