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also known as MBOAT4), a member of the membrane-bound O -acyltransferase (MBOAT) family, utilizes octanoyl-CoA as a donor to attach octanoic acid to Ser3, converting it into active ghrelin, which is then secreted into the bloodstream (Figure 1) (Gutierrez et al., 2008

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The absence of drug affinity complex modification results in a shorter receptor interaction window, allowing for transient activation that aligns with pulsatile signaling models

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