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Because glutamine metabolism involved in multiple pathways in cells and each pathway of glutamine metabolism has many regulatory factors, therefore, AML therapy targeting glutamine metabolism should focus on how to inhibit multiple metabolic pathways without affecting normal cells and host immune to achieve effective treatment for AML

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The pharmacokinetic and biopharmaceutical features of exogenous antioxidants and their ability to cross BBB to reach tumor sites should also be considered to achieve the desired therapeutic effect in brain cancer treatment