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The reported adverse reactions following parenteral administration of vitamin B12 include: Generalized: Anaphylaxis and death Cardiovascular: Pulmonary edema and congestive cardiac/heart failure during early treatment

A better question might be Are you absorbing enough B-12? As B12 levels decrease, homocysteine levels increase

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While its not always harmful, in some cases, it can indicate an underlying health condition, such as liver or kidney dysfunction, that warrants attention 3 , 5

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