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Effect of enzalutamide on time to first skeletal-related event, pain, and quality of life in men with castration-resistant prostate cancer: results from the randomised, phase 3 AFFIRM trial

2a & Supplementary Fig

As the engine of cell cycle, CDKs and their regulatory factors exert an important effect in disease progression

It may be explained by profibrotic factor-induced metabolic reprogramming from oxidative phosphorylation towards the glycolysis pathway

Cysteine also acts independently as an effective scavenger of free radicals, minimizing reactive oxygen species (e.g., OH, H2O2, and O2-) that damage deoxyribonucleic acid (DNA), proteins, and lipids in cells