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Non-steroidal anti-inflammatory drugs (NSAIDs): The long-term use of NSAIDs like ibuprofen can increase intestinal permeability and contribute to leaky gut (10,11,12)

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Comprehensive analysis of gut microbial community structural characteristics, metabolite characteristic profiles, and clinical phenotype information promises discovery of critical pathogenic pathways and potential intervention targets (163) Targeted metabolic pathway intervention trials: randomized controlled clinical studies directed at specific metabolic pathways should be designed

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