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kb glutathione website The Basics of Metabolic Dysfunction–Associated Steatotic Liver Disease for Cardiologists: Pathophysiology, Diagnosis, and Treatment Frontiers | Pharmacological effects, molecular

Name: kb glutathione website The Basics of Metabolic Dysfunction–Associated Steatotic Liver Disease for Cardiologists: Pathophysiology, Diagnosis, and Treatment Frontiers | Pharmacological effects, molecular
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doi: 10.1155/2019/7025251

10.1146/annurev.pharmtox.44.101802.121851

Although, zopolrestat and tolrestat were discontinued due to severe hepatotoxicity and an unfavorable risk-benefit profile observed in phase 2 and phase 3 clinical trials, respectively [150152], and ranirestat, which also progressed through phase 3 trial, focused primarily on diabetic polyneuropathy rather than cardiovascular outcomes [153]