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Having low-normal levels is considered beneficial and may reflect low oxidative stress and normal liver function

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In autoimmune disease, the immune system attacks healthy cells in the body leading to the destruction of platelets

In clinical populations, reduced BDNF levels in the entorhinal cortex and hippocampus have been correlated with low Mini-Mental State Examination (MMSE) scores, thereby underscoring the relationship between neurotrophic support and cognitive decline in AD (Wu et al., 2016)