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B85502, Invitrogen) cultured in flat culture flasks were grown until confluent in Express Five SFM Medium (Gibco) supplemented with 200 mM l-glutamine (Sigma-Aldrich) and 1 Antibiotic-Antimycotic solution (Sigma-Aldrich) at 27 C

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Besides, DEX significantly increases the renal excretion of urate (Li et al., 2019)