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Also, de Carvalho et al

10.1101/gr.172015.114 261 YuanB.LiaoF.ShiZ.-Z.RenY.DengX.-L.YangT.-T.et al (2020)

In obese patients, to meet the metabolic demands of the increased body weight, compensatory ultrafiltration occurs, increasing the intraglomerular pressure and damaging the kidneys through mechanisms such as lipotoxicity, chronic inflammation, and insulin resistance, increasing the risk of developing CKD (143)