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However, HSDs therapeutic application requires careful risk mitigation due to adverse effects including exacerbated irAEs with anti-CTLA-4 therapy (315), reduced Lactobacillus /butyrate with disrupted intestinal homeostasis (316), and multi-system toxicity (317321)

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Always, the dosage and frequency should be determined by a qualified healthcare provider familiar with the patients health status

[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Malnick S.D.H., Alin P., Somin M., Neuman M.G

But what exactly does it mean, and why is it important in ABA?