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156 On the other hand, another randomized controlled trial compared the effects of three different treatment approaches (120 mg ginkgo/day, 60 mg alpha-lipoic acid plus 600 mg vitamin C/day, and 100 mg papaverine hydrochloride [Pavacot, a vasodilating drug that increases brain blood flow] plus 400 mg vitamin E) to placebo in 58 tinnitus patients aged 60 years and older

Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate

PPAR is considered one of the master modulators of mitochondrial biogenesis and function and plays a crucial role in fat cell differentiation, lipid storage, vascular function, and energy metabolism ( Thiazolidinediones (TZDs) represent a class of compounds that are high-affinity ligands for the transcription factor PPAR (Villacorta et al., 2009)

Front Biosci 2022;27:256