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Supplementary material The Supplementary Material for this article can be found online at: References 1 AcanforaD.CerilloI.AcanforaC.PassarielloA.SalzanoA.NolanoM.et al

Simulation system equilibration and energy minimization Following preparation, the systems were energy minimized with an energy tolerance of 100 kj/mol and equilibrated in six sequential steps involving loosening of positional restraints on lipid atoms, protein backbone atoms, and protein side chain atoms (equilibration parameters in Extended Data Table 2)

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These benefits were associated with mitochondrial phenotypic changes such as upregulated anti-apoptotic proteins, reduced pro-apoptotic proteins and improved mitochondrial biogenesis and fusion (Jang et al., 2018)

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