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A distinctive pathological feature of ALS is the mislocalization and aggregation of phosphorylated TDP-43 (pTDP-43), a nuclear RNA-binding protein encoded by TARDBP

Geoditin A, an isomalabaricane triterpene compound derived from the South China Sea Sponge Geodia japonica, has been previously found to suppress melanogenesis by post-translational regulation in the endoplasmic reticulum and the degradation of TYR in the lysosome (123)

He was cognitively intact until a cerebral injury from an urgent cholecystectomy in the spring of 2019

GATA4 regulates angiogenesis and persistence of inflammation in rheumatoid arthritis

It is also sometimes combined with other treatments, like glutathione, for enhanced effects