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According to Meyer, the high doses of folic acid were necessary to treat the hematological irregularities in patients with pernicious anemia

Folic acid and vitamin B12 in pernicious anemia

This does not mean the treatment failed or that you are doing something wrong

Metformin is one of the most commonly prescribed drugs for type 2 diabetes and is well known to be associated with vitamin B 12 deficiency [19, 21, 22]