The above results demonstrated that FBI-1 can modulate the ferroptosis of PC-3 cells by enhancing the expression of GPX4
Notably, EXO miRNA sequencing combined with in vitro gain- and loss-of-function assays revealed that miR-128-3p, which is absent in the serum-derived EXOs of mice with PCOS, regulates lipid peroxidation and GC sensitivity to ferroptosis inducers
Resveratrol inhibits MAPK signaling pathways, such as p38 and c-Jun N-terminal Kinase (JNK), that regulate IL-1?, and modulate the gut-liver axis by enhancing gut barrier integrity and decreasing endotoxin translocation, indirectly reducing hepatic inflammation and IL-1
This research was funded by the National Natural Science Foundation of China, Number: 1760022
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