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The relevance of TM as the main Ca ++ store in the cochlea is in line with the later onset of TM during phylogenesis as a mechanism developed to further strengthen the effects of endolymph on both OHC SC and IHC SC [32]

Acid-suppressing medications are commonly used to treat conditions such as: Gastroesophageal reflux disease (GERD) Acid reflux Peptic ulcer disease Gastritis These medications work by reducing the amount of acid produced in the stomach, which may help relieve symptoms like heartburn and reflux

Moreover, vascular endothelial cells in the breast cancer microenvironment release several miRNAs ( miR-142-5p , miR-183-5p , and miR-222-3p ) that are transported through extracellular vesicles, and subsequently regulate macrophage remodeling and promote macrophage polarization toward the M2 phenotype 73 ( Figure 3H )

Hypermetabolism in ALS is associated with greater functional decline and shorter survival