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LD 50 s for intratracheal, subcutaneous, intraperitoneal, and intravenous administration are also presented in Table 4

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In many parts of the world, the soils are naturally deficient in iodine, and iodine deficiency and hypothyroidism will occur without iodine supplementation

Based on these data, an ongoing phase 1/2a, multicenter, open-label, ascending dose, first in-human clinical trial is planned to evaluate the safety of intracisternal PR001A (AAV9-GBA1) administration in patients with moderate to severe PD with at least one GBA pathogenic variant (NCT04127578, Table 2)

Polyethylene glycol and tromethamine were observed as potential allergens in mRNA vaccines, the Pfizer-BioNTech BNT162b2 vaccine, and the Moderna mRNA-1273