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PROVIDENCE, R.I

Develop personalized combination regimens (e.g., Met with antioxidants, probiotics, or insulin sensitizers) and evaluate their efficacy in well-designed randomized controlled trials

HOPE, hypothermic oxygenated machine perfusion

Solid tumor initially grows as an avascular bulk of cells carrying oncogenic mutations until diffusion distances from the nearest functional blood vessels limit delivery of nutrients and oxygen on the one hand and removal of metabolic waste on the other one

The aforementioned mechanisms, originating from in vitro primary cell models, indicate that ferroptosis in periodontal ligament fibroblasts serves as an active driver of soft tissue destruction