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in Hunger: Basic Mechanisms and Clinical Implications (eds Novin, D., Bray, G

Specific polyphenols, such as epicatechin and gallic acid, provide anti-inflammatory benefits by suppressing pro-inflammatory enzymes and cytokine synthesis, offering further protection for melanocytes 137

In stress + FFA treatment group, sugar-related metabolitesincluding 2-O-sulfo-idopyranuronic acid and glucoheptonic acidwere strongly elevated, suggesting enhanced osmotic regulation and carbohydrate turnover as part of an adaptive response

Oxidative stress is critical for the development of these diseases

Although gastrointestinal tolerability was not explicitly evaluated, metformin is associated with such adverse effects in clinical settings, a factor relevant for translational consideration