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Honokiol (HK), a biphenolic compound sourced from Magnolia bark, self-assembles into uniform spherical nanoparticles [68]

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The resulting GSH deficiency renders GPX4 nonfunctional, allowing uncontrolled accumulation of lipid peroxides that disrupt membrane integrity and trigger ferroptotic cell death (Dixon et al

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It has been suggested that metformin displays potential beneficial effects by reducing several cardiovascular dysfunction risk factors, such as body mass index (BMI) (MD: 0.53 kg/m 2 , 95% CI 0.95, 0.12), insulin-resistance (HOMA-IR) (MD:0.50, 95% CI 0.91, 0.09), triglyceride (MD: 0.11 mmol/L, 95% CI 0.20, 0.02), plasma plasminogen activator inhibitor-1 (Ruth, Day et al.) (MD: 4.99 ng/mL, 95% CI 6.78, 3.21) (Li and Li, 2023), carotid intima-media thickness (CIMT), and flow-mediated dilation (FMD) (Wang et al., 2024) in PCOS patients