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Thus, Notch receptors and ligands are key players in processes that promote the malignant potential of tumors ( DLL3 expression is regulated by the transcription factor ASCL1, which drives neuroendocrine cell differentiation and correlates with tumor-initiating potential ( Figure 2 ) ( Figure 2 In normal tissues, DLL3 expression is typically low or absent

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This induction occurs through the Sb9 promoter region by the transcription factor estrogen receptor (ER) ( Beyond the endogenous regulators, exogenous compounds have also been shown to affect the expression of Sb9