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Importantly, the inability of tir-1 RNAi treatment to increase further the arsenite-sensitivity of pmk-1 mutant animals (Figure 5D) suggests impaired PMK-1 activation underlies the arsenite-sensitivity of TIR-1-deficient animals (Figure 5)

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PLC- is expressed in a tissue-specific manner and shows different sensitivities toward G-protein-mediated activation (Kadamur and Ross, 2013)

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