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Commonly reported observations include: Reduced joint stiffness, particularly morning stiffness Improved range of motion in affected joints Decreased reliance on anti-inflammatory medications Better tolerance of physical activity and exercise These clinical observations are valuable but represent anecdotal evidence

Plasma lipid-profile measurements showed that the total cholesterol levels were 30% lower in treated DIO mice relative to control DIO mice (P 0.05

Moreover, NNMT might contribute to hyperlipidemia by influencing plasma Hcy levels

Occasional side effects include mild nausea, loss of appetite, diarrhoea, or injection-site reactions such as pain or hardening