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These are not only damaging, but they can also single-handedly deplete glutathione, creating an imbalance between Phase 1 and Phase 2 (see below) activity.7 Toxic reactions can occur due to the buildup of reactive intermediate forms resulting from phase 1 detoxification, so further work needs to be done to process and eliminate toxins

To review the bodies of evidence, we systematically screened on PubMed/MEDLINE, Cochrane Library, and Web of Science from the database inception to March 22, 2023

(PubMed) Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G

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Cryo-EM data processing and model building CryoSPARC (v4.3.1) was used for all CryoEM data processing steps 119