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Watanabe et al., 2022

Apply a rice-grain amount with your ring finger, tapping gently from inner to outer corner

The HC did not fulfill the exclusion criteria above, were devoid of chronic pain, and did not take regular sleep medication, antidepressants, NSAIDs, analgesics, or anticonvulsants

Similarly, the use of valproic acid at high doses used by patients can have noteworthy effects on the gut microbiota, altering the biosynthesis of fatty acid by different microorganisms [270]