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Due to the random nature of Birdshot label-free quantitative proteomics, protein identification or abundance data are sometimes missing in some samples [38]

doi: 10.1016/j.phymed.2024.155560 37 JungJLeeSMLeeMJRyuJSSongJHLeeJEet al

In this study, we found that induced pluripotent stem cell (iPSC)-derived human dopaminergic (DA) neurons form LB-like inclusions after treatment with -synuclein preformed fibrils (PFFs) but only when coupled to a model of immune challenge (interferon- or interleukin-1 treatment) or when co-cultured with activated microglia-like cells

A previous work has demonstrated that HFD induces the production of reactive oxygen species (ROS), lowers the expression of antioxidant genes, and upregulates the expression of proinflammatory cytokines in the RPE (Biswas et al., 2021)