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1988, 255: E322-31

ROS may be implicated in the regulation and responsiveness of stress sensors by enhancing the antioxidant defense via p53 to maintain cellular redox balance and by indirectly modulating selective transactivation of p53 target genes [35]

The authors concluded that probiotic and prebiotic supplementation exerts measurable antioxidant and anti-inflammatory effects in this model, supporting their potential as complementary neuroprotective strategies (Alsubaiei et al., 2023)