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The better option depends on the condition being treated

Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development

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[2] Raun K, Hansen BS, Johansen NL, Thgersen H, Madsen K, Ankersen M, Andersen PH

GPx1 deficiency may also (partially) protect liver hepatocytes against acetaminophen-mediated toxicity by mechanisms that decrease protein nitration and cell death, whereas GPx1 overexpressing mice are more sensitive to acetaminophen-mediated hepatotoxicity, in part due to an exhaustion of GSH [175]