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Other optic neuropathies are associated with autoimmune disorders such as systemic lupus erythematosus (SLE), Sjgrens syndrome, autoimmune thyroiditis, and myasthenia gravis [168, 169], often coinciding with NMO-ON

According to the recently proposed Acidic Exposure model, acidic residues alternate with hydrophobic residues within an acidic TAD, and electrostatic repulsion among the acidic side chains exposes the hydrophobic residues to solvent, allowing coactivator engagement 68,69

(2018) 115:E1289e1298

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Current pharmacological interventions primarily target acetylcholine deficiency and amyloid plaque formation, but offer limited efficacy and are often associated with adverse effects