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Importantly, diselenide linkages are dual-responsive, as they are susceptible not only to GSH reduction but also to oxidation by reactive oxygen species (ROS), such as hydrogen peroxide [59]

doi: 10.1155/2015/412501

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Dual regulation of heat-shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin

According to the American Diabetes Association, prediabetes can be defined by a condition of impaired fasting glucose, characterized by a fasting blood glucose concentration between 100 mg/dL and 125 mg/dL and/or a condition of impaired glucose tolerance, characterized by a 2-hour blood glucose concentration 140 mg/dL following an oral glucose tolerance test (56)