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et al, Results of B-vitamin supplementation study used in a prediction model to define a reference range for plasma homocysteine

Heliyon 9 , e20163 (2023)

PMCID: PMC5626850

This irreversible reaction catalysed by MTHFR is crucial in the folate metabolism cycle because it regulates the bioavailability of 5-methyl-THF, which is required for Met synthesis