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However, because of their poor thermodynamic stability, aging of dosage forms containing such metastable forms usually result in formation of less soluble, stable polymorphfor example, the more soluble crystalline form II of cortisone acetate converts to the less soluble form V in an aqueous suspension resulting in caking of solid

These biomarkers can be used in adjunct to MTT assay for a more accurate prediction of the in vivo response

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Increased skin density and thickness, reduced fine lines and wrinkles, and improved skin clarity were observed in women treated with GHK-Cu as compared to placebo [2]

One study posited that a GHK-Cu possibly reduces visible bioindicators, improving skin laxity and clarity