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Figures 2, 4) availability is maintained by de novo synthesis from precursor amino acids, (glutamate, cysteine, and glycine), reduction of GSSG by glutathione reductase (GR), and uptake from exogenous GSH sources across plasma membranes (Figure 4) (62, 63)

Across the published trials in Stier et al

Different patient populations, different trial designs, different enrollment criteria, and different measurement protocols all introduce noise that makes precise numerical comparisons between CagriSema and tirzepatide unreliable

Metabolism 139 , 155377 (2023)