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i) LASSS-treated HGF, at as low as 1 ng/ml that is below 2.510 ng/ml of the optimal final-concentration range in culture media (supplementary Figure 1a, left light-blue bar ), activates satellite cells to the maximum level presented by the positive control ( black bar PC , 5 ng/ml HGF)

These studies help to determine the absorption, distribution, metabolism, and excretion profiles of combination agents, characterize their immunomodulatory effects and kinetics in terms of drug concentrations, identify any undesirable effects or toxicities arising from combination use, and inform personalized treatment approaches according to patient-specific factors and disease activity

This work was supported by the Ministry of Education and Science of the Russian Federation within the fundamental research on the subject Development of strategies for diagnostics, therapy of genital endometriosis and tumors of the female reproductive tract (registration number: AAAA-A19-119030490009-6)

doi: 10.3390/ijms19041197 196