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The balance between normal cellular oxidation and antioxidants must be maintained, as excess copper levels can induce oxidative stress, leading to cell death and cardiovascular disease (14)

Misclassification bias and missing data are also possible

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reported lower GPX3 activity in individuals who died from CVDs compared to controls, revealing a linear and inverse relationship between serum GPX3 activity and CVDs mortality in individuals with low HDL, encompassing conditions such as coronary heart disease, other atherosclerotic diseases, and stroke [64]