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*Correspondence: BuHyun Youn, [email protected] These authors have contributed equally to this work This article was submitted to Epigenomics and Epigenetics, a section of the journal Frontiers in Genetics Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

It was discovered in 1973 and has had decades of research for wound healing and skin improvement

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Therefore, it is speculated to be a multi-factorial disorder, involving epigenetics, genetics and environmental factors

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