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This can show up as insomnia and migraines 7

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ACS Chem Neurosci 12(13):25422552 Ali AE, Mahdy HM, Elsherbiny DM et al (2018) Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: impact on oxidative, inflammatory and apoptotic machineries [J]

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DNA glycosylases While DNA helicases and polymerases aim to perform high-fidelity DNA replication to avoid replication stress, damage to DNA bases can occur through several different chemical modifications including oxidation, alkylation, deamination, and spontaneous hydrolysis (Wallace, 2013)