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In the limbs, the symptoms of edema include swelling of the subcutaneous tissues, an increase in the normal size of the limb, and stretched, tight skin

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This increase in bioavailability can be achieved by the synergistic action of (i) a pH adjusting agent that increases the pH of the gastrointestinal tract environment to a pH value favorable for dissolution of the peptide and (ii) a permeation enhancer excipient present in the formulation

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